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News: This Genetic Defect Could Be Why Typhoid Mary Never Got Typhoid Fever

Whether or not a microbe is successful at establishing an infection depends both on the microbe and the host. Scientists from Duke found that a single DNA change can allow Salmonella typhi, the bacteria that causes typhoid fever, to invade cells. That single genetic variation increased the amount of cholesterol on cell membranes that Salmonella and other bacteria use as a docking station to attach to a cell to invade it. They also found that common cholesterol-lowering drugs protected zebrafi...

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